Conclusion The results demonstrate quantitative accuracy to better than 10%, and both consistent SUV calculation between 2 different SPECT/CT scanners for 9 tissues, and low intrapatient measurement variability for quantitative SPECT/CT analysis in a pediatric population with neuroblastoma. In one patient, a thoracic tumor evaluated over 10 time points (18 months) underwent a 74% (3.1/12.0) reduction in maximum SUV with treatment. Intrapatient liver mean SUV varied 16% as calculated for 28 patients (87 examinations) studied on both scanners. Interscanner SUV variability showed no statistical difference (average p value 0.559 range 0.066-1.0) among the 9 normal tissues analyzed. Results The phantom results of the visible spheres and background resulted in accuracy calculations better than 5-10% with CRC correction. The intensity of uptake by neoplastic tissue in the images was quantified using maximum SUV and, if present, compared over time. Intrapatient mean SUV variability was calculated by measuring normal liver uptake within patients scanned on both cameras.

Inter scanner SUV analysis of 9 regions of normal mIBG tissue uptake was conducted. One hundred eleven 123I-metaiodobenzylguanidine ( mIBG) SPECT/CT examinations from 43 patients were reconstructed using SUV SPECT® (HERMES Medical Solutions Inc.) 42 examinations were acquired using a GE Infinia Hawkeye 4 SPECT/CT, and 69 were acquired on a Siemens Symbia Intevo SPECT/CT. Methods A NEMA body phantom with 6 spheres (ranging 10-37 mm) was filled with a known activity-to-volume ratio and used to determine the contrast recovery coefficient (CRC) for each visible sphere, and the measured SUV accuracy of those spheres and background water solution.

Abstract : Purpose To determine the accuracy of quantitative SPECT, intersystem and interpatient standardized uptake value (SUV) calculation consistency for a manufacturer-independent quantitative SPECT/CT reconstruction algorithm, and the range of SUVs of normal and neoplastic tissue.

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